Dirk Paul Bogner widmet sich der Frage, welche Relevanz Kurt Lewins Feldtheorie im Bereich der pädagogischen Diagnostik haben könnte. Er untermauert die These, dass die Lewin’sche Feldtheorie eine völlig neue Sicht auf Lern-, Entwicklungs- und Erziehungsprozesse eröffnen würde, und legt dar, inwiefern die Einbeziehung der Dimension des Raumes die Analyse dieser erziehungswissenschaftlich relevanten Topoi verfeinern könnte. Er erörtert mittels hermeneutischer Textauslegung und vergleichender Dokumentenanalyse, warum Lewin keine erziehungswissenschaftliche Resonanz erzeugen konnte, obwohl in der Erziehungswissenschaft auch heute noch (...) intensiv Begriffe, die entweder direkt aus der Feldtheorie stammen oder aber von dieser konsequent definiert wurden, verwendet werden. (shrink)

Understanding the functional mechanisms underlying genetic signals associated with complex traits and common diseases, such as cancer, diabetes and Alzheimer's disease, is a formidable challenge. Many genetic signals discovered through genome‐wide association studies map to non‐protein coding sequences, where their molecular consequences are difficult to evaluate. This article summarizes concepts for the systematic interpretation of non‐coding genetic signals using genome annotation data sets in different cellular systems. We outline strategies for the global analysis of multiple association intervals and the in‐depth (...) molecular investigation of individual intervals. We highlight experimental techniques to validate candidate (potential causal) regulatory variants, with a focus on novel genome‐editing techniques including CRISPR/Cas9. These approaches are also applicable to low‐frequency and rare variants, which have become increasingly important in genomic studies of complex traits and diseases. There is a pressing need to translate genetic signals into biological mechanisms, leading to prognostic, diagnostic and therapeutic advances. (shrink)

English summary: It seems that reason is less a universal principle than something inherently bound to the contexts in which it appears. These contributions to a conference held on the occasion of Christoph Schwobel's 60th birthday explore the character of reason's manifold contexts: the grounding of reason in the inner word of God 's Trinitarian life as well as the disclosure of reason and and its limits in human conversation. German description: Vernunft scheint in der Gegenwart weniger ein allgemeines Prinzip (...) als eine in Kontexte eingebundene Grosse zu sein. Die Beitrage einer Tagung anlasslich von Christoph Schwobels 60. Geburtstag, gehen der Frage nach dem Charakter dieser Kontextbindung nach: der Begrundung der Vernunft im trinitarischen Gesprach wie der Erschliessung und Problematisierung der Vernunft im menschlichen Gesprach. Mit Beitragen von V. Brummer, G. van den Brink, C. Drobe, H. J. Eckstein, D.-M. Grube, J. Halfwassen, S. Heine, F. Hermanni, E. Herms, W. Harle, W. Homolka, W. Jeanrond, R. W. Jenson, D. Kelsey, A. F. Koch, A. Kupsch, V. Leppin, P.-C. Lai, P. Lo, A. Min, J. Moltmann, M. Muhling, P. Peterson, M. Sarot, F. Schweitzer, A. Torrance, J. Webster, M. Welker, M. Wendte, M. Wisse, H. Wisskirchen und L. Zak. (shrink)

After the moral framework of sustainable development, the focus on climate change appears to take a lead in the practice and theory of environmental education. Inherent in this perspective is an apocalyptic message: if we do not rapidly change our use of energy resources, we will severely harm the life conditions of our children and grandchildren. In this article we argue that environmental educators should liberate us from this highly instrumental dictate by taking their cue from our daily care for (...) our environment as revealed in child?s play in nature. Inherent in the interaction of the Homo ludens with nature is a spiral time experience. This time condition elicits a particular responsibility: rather than calculating which means are necessary to prevent future disasters, we should respond with care to the concentric circles of an open and indefinite future. Therefore, environmental education should not aim to prevent future disasters, but foster anticipating care for nature. (shrink)

This handbook presents a comprehensive introduction to the core areas of philosophy of education combined with an up-to-date selection of the central themes. It includes 95 newly commissioned articles that focus on and advance key arguments; each essay incorporates essential background material serving to clarify the history and logic of the relevant topic, examining the status quo of the discipline with respect to the topic, and discussing the possible futures of the field. The book provides a state-of-the-art overview of philosophy (...) of education, covering a range of topics: Voices from the present and the past deals with 36 major figures that philosophers of education rely on; Schools of thought addresses 14 stances including Eastern, Indigenous, and African philosophies of education as well as religiously inspired philosophies of education such as Jewish and Islamic; Revisiting enduring educational debates scrutinizes 25 issues heavily debated in the past and the present, for example care and justice, democracy, and the curriculum; New areas and developments addresses 17 emerging issues that have garnered considerable attention like neuroscience, videogames, and radicalization. The collection is relevant for lecturers teaching undergraduate and graduate courses in philosophy of education as well as for colleagues in teacher training. Moreover, it helps junior researchers in philosophy of education to situate the problems they are addressing within the wider field of philosophy of education and offers a valuable update for experienced scholars dealing with issues in the sub-discipline. Combined with different conceptions of the purpose of philosophy, it discusses various aspects, using diverse perspectives to do so. Contributing Editors: Section 1: Voices from the Present and the Past: Nuraan Davids Section 2: Schools of Thought: Christiane Thompson and Joris Vlieghe Section 3: Revisiting Enduring Debates: Ann Chinnery, Naomi Hodgson, and Viktor Johansson Section 4: New Areas and Developments: Kai Horsthemke, Dirk Willem Postma, and Claudia Ruitenberg. (shrink)

Activation of resting T lymphocytes through the T cell antigen receptor complex is initiated by critical phosphorylation and dephosphorylation events that regulate the function and interaction of a number of signaling molecules. Key elements in these reactions are members of the Src, Syk and Csk families of protein tyrosine kinases (PTKs) and the phosphotyrosine phosphatases (PTPases) that regulate and/or counteract them, such as CD45. The PTKs can autophosphorylate and phosphorylate each other at multiple sites and, as the result of these (...) interactions, they are induced to phosphorylate other cellular proteins. These phosphorylation events lead to modulation of enzymatic activities and/or serve as binding sites for other signaling molecules having phosphotyrosine‐binding Src homology 2 (SH2) domains. As a result, these proteins translocate to the receptor complexes and are juxtaposed to the kinases that phosphorylate them. Some of the SH2‐domain‐containing polypeptides lack enzymatic activities and, instead, serve as adapter molecules that couple the signal to downstream effectors, such as regulators of the Ras proteins, and further into serine/threonine‐specific protein kinase cascades. Through largely unknown steps these reactions lead to the transcription of previously silent genes, activation of lymphocyte effector functions, progression through the cell cycle and cell proliferation. (shrink)

Appraisal theories of emotions have gained widespread acceptance in the field of emotion research (for a recent overview, see, e.g., Scherer, Schorr, & Johnstone, 2001). In these theories, it is as...

Epigenetic and transcriptional variability contribute to the vast diversity of cellular and organismal phenotypes and are key in human health and disease. In this review, we describe different types, sources, and determinants of epigenetic and transcriptional variability, enabling cells and organisms to adapt and evolve to a changing environment. We highlight the latest research and hypotheses on how chromatin structure and the epigenome influence gene expression variability. Further, we provide an overview of challenges in the analysis of biological variability. An (...) improved understanding of the molecular mechanisms underlying epigenetic and transcriptional variability, at both the intra- and inter-individual level, provides great opportunity for disease prevention, better therapeutic approaches, and personalized medicine. Epigenetic and transcriptional variability mediate phenotypic plasticity, enabling adaptation to changing environments. In this review, we describe the sources of inter- and intra-individual variability and discuss epigenetic regulators of gene expression variability, including DNA methylation and chromatin structure. Understanding these molecular mechanisms will improve therapeutic approaches and personalized medicine. (shrink)

The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)

The rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the “phase 2” of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens’ privacy (...) and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens’ “personal data stores”, to be shared separately and selectively, voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allow the user to share spatio-temporal aggregates—if and when they want and for specific aims—with health authorities, for instance. Second, we favour a longer-term pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society. (shrink)

A new look at analogical reasoning Content Type Journal Article Pages 1-5 DOI 10.1007/s11016-011-9563-z Authors Dirk Schlimm, Department of Philosophy, McGill University, Montreal, QC H3A 2T7, Canada Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

In dieser Aufsatzsammlung werden die Probleme und Konsequenzen des Offenbarungsbegriffs im Denken Paul Tillichs untersucht. Zunächst wird dieser Begriff näher thematisiert anhand der Fragen, wie dieser gewonnen wird und welche Rolle dabei die Phänomenologie spielt, ob dessen Ausarbeitung zu stark von subjektivistischen Voraussetzungen geprägt ist und wie sich die Offenbarungserkenntnis zur wissenschaftlichen Erkenntnis verhält.Im Anschluss daran werden charakteristische Aspekte von Tillichs Theologie analysiert: sein Postulat mystischer Unmittelbarkeit als Grund von Offenbarung, die Frage nach der Rolle der Erfahrung bei der (...) Begründung von Offenbarungserkenntnis, seine Korrelationsmethode, d.h. die Zuordnung von philosophischen Fragen und theologischen Antworten, sowie die Bedeutung von Tillichs Christologie - in der Spannung zwischen absoluten Geltungsansprüchen und deren Relativierung - für den interreligiösen Dialog heute. Auf diese Weise wird deutlich, dass die Impulse von Tillichs Ansatz von bleibender Bedeutung für die gegenwärtige Theologie sind, besonders was das Gespräch mit den nicht-christlichen Religionen und der Philosophie angeht. (shrink)

Carl Friedrich Lehmann-Haupt: Ein Forscherleben zwischen Orient und Okzident. Edited by Sebastian Fink; Klaus Eisterer; Robert Rollinger; and Dirk Rupnow. Classica et Orientalia, vol. 11. Wiesbaden: Harrassowitz Verlag, 2015. Pp. vi + 217, illus. €48.

“Neo-inclusivism” is explained and assessed as an approach to the problem of the conflicting claims to truth of different religions, with reference to inter alia John B. Cobb (Jr.), Gavin D'Costa and Paul Ingram. For the neo-inclusivist the truth of a religious tradition depends on its inclusivistic capacity, i.e. its capacity to assimilate other traditions. For ex ample, by being enriched and transformed through “radical openness” to other traditions, while remaining “committed” to her own tradition – so the neo-inclusivist (...) claims – the theology of the Christian can become “truly global”. Neo-inclusivism seemingly transcends the absolutist habits of inclusivists, i.e. to assess the religious other in view of criteria (the inclusivist's own religious tradition) with which the other does not identify himself or herself. However, the neo-inclusivist plays down the possible limits of inter religious openness and is overly optimistic about the possibility of a “truly global” theology. Moreover, whether the neo-inclusivist's “committed openness” significantly differs from the approach of those who arbitrarily use the definitive norms of their own religious tradition to assess other traditions, is at least debatable. Whatever the case may be, insofar as tolerance cannot tolerate intolerance, the neo-inclusivist is necessarily intolerant, and, in this sense, “absolutist”, towards those who make their own beliefs normative for all and shun themselves from the assessments and new insights of others. S. Afr. J. Philos. Vol.23(1) 2004: 82-107. (shrink)

Do adherents of different religious traditions communicate and, if so, how? What enables them to do so? What is interreligious “communication”? These issues are ad dressed with reference to Wilfred Cantwell Smith's hermeneutical rule, and to inter alia Paul Knitter, Martin Heidegger, Hans-Georg Gadamer, David Tracy, and John Dunne. Four responses to the question as to what permits interreligious communication are criticised. According to a fifth response, on which the author elaborates, interreligious communication is not – as the objectivist (...) claims – possible because members of different religious traditions speak the very same language, or – as the relativist claims – impossible because they speak radically different languages. Adherents of different religions communicate, if at all, by means of an analogical language. This language is the product of persistent efforts to understand the religion/faith of the other as he or she understands it. Paradoxically, the language that permits inter religious communication is thus the product of such communication. Without thereby reverting to objectivism or an essentialist view of religion, the author identifies five “less unstable” similarities between religions. These and other “less un stable” similarities might assist believers in their efforts to under stand the religious other. (shrink)

John Rawls wordt algemeen beschouwd als een van de meest invloedrijke filosofen van de voorbije eeuw. In zijn befaamde boek 'A Theory of Justice' uit 1971 staat het principe van de rechtvaardigheid centraal dat hij beschouwt als de belangrijkste maatschappelijke waarde in de samenleving. Mensen zijn fundamenteel gelijkwaardig. Daarom is het voor Rawls evident dat een ethisch systeem zich richt tot iedereen. Natuurlijk beseft hij dat mensen niet gelijk zijn of beter gezegd, niet over dezelfde begaafdheden beschikken noch over dezelfde (...) startposities. Waar het bij hem op aan komt is de onvrijwillige achterstanden, dus achterstanden die niet gebaseerd zijn op vrijwillige keuze, weg te werken. De denktank Liberales organiseerde tussen 2012 en 2016 vijf John Rawlslezingen. Ze werden gehouden door schrijver en oud-politicus Jan Terlouw, en de hoogleraren Frank Vandenbroucke, Paul Cliteur, Philippe Van Parijs en Patrick Loobuyck. De inleidingen werden gegeven door de Liberales-kernleden Daniël Boomsma, Claude Nijs, Kasper Ossenblok, Andreas Tirez en Dirk Verhofstadt. 0Het doel van deze lezingen was om het gedachtegoed van Rawls bekend te maken bij een breder publiek en te toetsen aan de hedendaagse politieke, sociaaleconomische en maatschappelijke omstandigheden. In dit boek zijn de John Rawlslezingen en de inleidingen gebundeld. (shrink)

Der Aufsatz stellt zunächst das konstruktive Abstraktionsverfahren von Paul Lorenzen vor, das eine Bezugnahme auf Mengen vermeidet und daher gestattet, den Terminus ‚Menge‘ selbst als einen Abstraktor einzuführen. Es werden dann weiter häufig übersehene Konsequenzen des Abstraktionsverfahrens für die Rede von abstrakten und konkreten Gegenständen aufgezeigt. Schließlich werden die Inkonsistenzbeweisversuche von Geo Siegwart dargestellt und kritisch diskutiert. Dabei wird gezeigt, dass diese darauf beruhen, dass die besagten Konsequenzen nicht berücksichtigt werden.

In the first part of this essay, some of the strategies atheists use to claim undeserved privileges for their position are analyzed. In particular, the connection between evidentialism and the idea that atheism is the natural starting position (“presumption of atheism”, Anthony Flew) is discussed. In addition, the extent to which the elimination of agnosticism as the third option between theism and atheism contributes to the discursive privilege of atheism is examined (with Paul Cliteur). In the second part, evidentialism (...) is reconstructed as a context-dependent theory of justification and the (A) theism problem is situated in the context of action instead of the context of knowledge. This avoids one-sided distribution of the burden of justification, especially the atheistic attempt to to burden the theist with the full burden of justification and at the same time to free the atheist from all burdens of justification. In this way, the discourse on the (a) theism problem can be reconstructed without assigning undeserved privileges. (shrink)

The Spirit (πνεῦμα) and peace (εἰρήνη) with God as opposed to the Flesh (σάρξ) and hostility (ἔχθρα) with God in Romans 8:6–8. A surprising number of exegetes do not address the question to what exactly εἰρήνη refers in Romans 8:6. The rest seem to be divided between interpreting it as an unspecified (eschatological) state of peace (šalôm), peace with one’s fellow humans, or peace with God. Based on the textual context, this article argues that the latter interpretative option is best. (...) In terms of metaphor, the relevant target domain here is that of the relationship with God, while the source domain reflected probably is that of diplomatic relations. In addition, peace (with God) here must be understood in relation to the rule of the Spirit, the decisive influence upon those who live κατὰ πνεῦμα (Rom 8:4–5). Antithetically, personified flesh rules over those who are ἐν σαρκί (Rom 8:8). This leads to a disposition of enmity toward God as well as the inability to submit to his law. For Paul being ruled by the Spirit, as a consequence of being reconciled with God through Christ (Rom 5:1, 10; 8:3–4), is a crucial aspect of being at peace with God. (shrink)

The fifteen essays in this volume, rooted in the work of the Hellenistic Moral Philosophy and Early Christianity Section of the SBL, examine the works of Philodemus and how they illuminate the cultural context of early Christianity. Born in Gadara in Syria, Philodemus (ca. 110-40 BCE) was active in Italy as an Epicurean philosopher and poet. This volume comprises three parts; the first deals with Philodemus' works in their own terms, the second situates his thought within its larger Greco-Roman context, (...) and the third explores the implications of his work for understanding the earliest Christians, especially Paul. It will be useful to all readers interested in Hellenistic philosophy and rhetoric as well as Second Temple Judaism and early Christianity. (shrink)

Die Kontroversen um Imre Lakatos' "Methodologie wissenschaftlicher Forschungsprogramme" haben zu der Frage geführt, ob auf Basis der von Lakatos entwickelten Standards für die Bewertung von konkurrierenden Theorien und Forschungsprogrammen auch heuristische Empfehlungen begründet werden können, die die von Wissenschaftlern auszuführenden Handlungen im Interesse der Maximierung von Erkenntnisfortschritt normieren. Eine solche Frage steht im Zusammenhang mit einem zentralen Anliegen der Popperschen Wissenschaftstheorie: "Wir wollen die Regeln, oder, wenn man will, die Normen aufstellen, nach denen sich der Forscher richtet, wenn er Wissenschaft (...) treibt, wie wir es uns denken". Ob die Methodologie wissenschaftlicher Forschungsprogramme, die Lakatos als Weiterentwicklung des kritisch-rationalistischen Falsifikationismus verstanden wissen will, diesen Ansprüchen genügt, wurde zuerst von Paul K. Feyerabend und Thomas S. Kuhn bezweifelt. Im folgenden werden zunächst deren Kritiken, die Antworten von Lakatos sowie Analysen von J. J. C. Smart, Wolfgang Stegmüller und Philip Quinn diskutiert. Anschließend wird ein neuer Versuch Alan Musgraves kritisch überprüft, unter Rückgriff auf die Bewertungskriterien der Methodologie wissenschaftlicher Forschungsprogramme heuristische Empfehlungen zu begründen. (shrink)

Du sommaire: Ambiguite et comprehension du langage (Paul Bogaards, Johan Rooryck). - Why pluralities don't mean a thing (Crit Cremers). - Aspects of interlingual ambiguity: polyglot punning (Dirk Delabastita). - Les feux de Saint-Antoine (Sjef Houppermans). - The semantics of Dutch moeten 'must, should, have to' from a typological and a relevance-theoretical perspective (Theo Janssen). - L'ambiguite en langue et en discours (Catherine Kerbrat-Orecchioni).".

Volume 1 of this biography of L. E. J. Brouwer was published in 1999.1 The volume under review here covers the period from the early nineteen twenties until Brouwer's death in 1966. It also includes a short epilogue that discusses the disposition of Brouwer's estate after his death, his influence on others, the paths of some of his students and colleagues, and other matters. Van Dalen notes in the Preface that in preparing this volume he consulted some historical studies that (...) appeared after the first volume was published. He also used new material from various archives. The biography contains interesting quotations from unpublished materials in the Brouwer Archive and from correspondence. The bibliographical references to Brouwer's publications, it should be noted, are somewhat different in this volume. This volume, like the first, contains some nice photographs and reproductions. I noted that there were many typographical errors in the earlier book but Volume 2 is relatively free of them.As is the case in Volume 1, the discussion of Brouwer's mathematical and philosophical work is woven into the narrative of Brouwer's life and times. The story in this volume starts with Brouwer's first contacts with Paul Alexandrov and Paul Urysohn in 1923. The interaction began when Urysohn announced that he had found a mistake in Brouwer's definition of dimension in Brouwer's 1913 paper on natural dimension. Was it just a slip of the pen, as Brouwer always maintained , or something more substantial? Urysohn and Alexandrov ultimately came to agree with Brouwer on the matter, and Urysohn was prepared to grant Brouwer priority for the definition of dimension. There were, however, ups and downs along the way. Karl Menger, through his own work in topology and dimension theory, soon got into the picture, and Brouwer and Menger were to …. (shrink)

Paul Weithman offers a fresh, rigorous, and compelling interpretation of John Rawls's reasons for taking his so-called "political turn.".